Dorothea B. Heitsch is Assistant Professor of French and German at Shippensburg University in Pennsylvania.

A Scientific Integrity Consortium developed a set of recommended principles and best practices that can be used broadly across scientific disciplines as a mechanism for consensus on scientific integrity standards and to better equip scientists to operate in a rapidly changing research environment. The two principles that represent the umbrella under which scientific processes should operate are as follows: Foster a culture of integrity in the scientific process. Evidence-based policy interests may have legitimate roles to play in influencing aspects of (...) the research process, but those roles should not interfere with scientific integrity. The nine best practices for instilling scientific integrity in the implementation of these two overarching principles are Require universal training in robust scientific methods, in the use of appropriate experimental design and statistics, and in responsible research practices for scientists at all levels, with the training content regularly updated and presented by qualified scientists. Strengthen scientific integrity oversight and processes throughout the research continuum with a focus on training in ethics and conduct. Encourage reproducibility of research through transparency. Strive to establish open science as the standard operating procedure throughout the scientific enterprise. Develop and implement educational tools to teach communication skills that uphold scientific integrity. Strive to identify ways to further strengthen the peer review process. Encourage scientific journals to publish unanticipated findings that meet standards of quality and scientific integrity. Seek harmonization and implementation among journals of rapid, consistent, and transparent processes for correction and/or retraction of published papers. Design rigorous and comprehensive evaluation criteria that recognize and reward the highest standards of integrity in scientific research. (shrink)

The transcription factor NF‐κB (p65/p50) plays a central role in the coordination of cellular responses by activating the transcription of numerous target genes. The precise role of the dynamics of NF‐κB signalling in regulating gene expression is still an open question. Here, we show that besides external stimulation intracellular parameters can influence the dynamics of NF‐κB. By applying mathematical modelling and bifurcation analyses, we show that NF‐κB is capable of exhibiting different types of dynamics in response to the same stimulus. (...) We identified the total NF‐κB concentration and the IκBα transcription rate constant as two critical parameters that modulate the dynamics and the fold change of NF‐κB. Both parameters might vary as a result of cell‐to‐cell variability. The regulation of the IκBα transcription rate constant, e.g. by co‐factors, provides the possibility of regulating the NF‐κB dynamics by crosstalk. (shrink)

Introduction Dorothea Frede and Brad Inwood 1. The Stoics on the origin of language and the foundations of etymology James Allen 2. Stoic linguistics, Plato's Cratylus, and Augustine's De dialectica A. A. Long 3. Epicurus and his predecessors on the origin of language Alexander Verlinsky 4. Lucretius on what language is not Catherine Atherton 5. Communicating cynicism: Diogenes' gangsta rap Ineke Sluiter 6. Common sense: concepts, definition and meaning in and out of the Stoa Charles Brittain 7. Varro's anti-analogist (...) David Blank 8. The Stoics on fallacies of equivocation Susanne Bobzien 9. What is a disjunction? Jonathan Barnes 10. Theories of language in the Hellenistic age and in the twelfth and thirteenth centuries Sten Ebbesen. (shrink)

Our goal was to explore self‐care practices among men who have sex with men in the context of Mpox in Brazil. This study used qualitative research methods, including interviews and thematic analysis, to collect and analyze data from male participants across the Brazilian territory. The narratives unveil men's perspectives on self‐care, risk reduction, and health beliefs during the Mpox pandemic. Our findings highlight a multifaceted approach to self‐care among men, encompassing hygiene, physical contact management, mask usage, skin lesion vigilance, and (...) adherence to official guidelines. Men's attitudes toward sexual behaviors emphasize the importance of reducing sexual partners, practicing safe sex, and combating misinformation through accurate information dissemination. The development of these behaviors and self‐care practices can be facilitated by nurses guided by Dorothea Orem's Self‐Care Theory, supported by patient‐centered care, with strategies to address and confront the stigma associated with the disease and provide emotional support. Thus, the study underscores the pivotal role of self‐care in mitigating infection risks, especially in the context of emerging infectious diseases. It acknowledges the impact of socio‐cultural factors and healthcare policies on men's preventive measures. However, it also recognizes limitations, such as potential bias due to stigma concerns and a nonrepresentative sample. Ultimately, the research advocates for tailored education, promotion of gender equity, and healthcare empowerment to effectively manage health risks in such contexts. (shrink)

Zwischen Johann Gottlieb Fichte, dem Philosophen der „abstrakten Denkkünsteleien“ (Husserl), und Jean-Paul Sartre, dem Existentialisten, der sich von der Phänomenologie faszinieren ließ, weil man damit selbst über ein Glas Bier philosophieren könne, scheinen Welten zu liegen. Umso überraschender ist das Resultat der vorliegenden Studie, die aufzeigt, daß sich wesentliche Argumentationsweisen und Resultate von Sartres Selbstbewußtseinstheorie vor dem Hintergrund der Fichteschen Transzendentalphilosophie interpretieren und einsichtig machen lassen. Während Sartre bisher zumeist mit Husserl, Heidegger oder Hegel in Verbindung gebracht wurde, stellt diese (...) Arbeit die erste Monographie dar, die die Theorie Sartres in _Das Sein und das Nichts_ aus der Perspektive des frühen Fichte in den Blick nimmt. Dessen _Grundlage der gesammten Wissenschaftslehre_ von 1794/95 dient der Autorin als Interpretationsfolie, vor der die grundlegenden Elemente von Sartres Ansatz untersucht werden: Die Konstitution des Für-sich in ihrem apriorischen Bedingungsgefüge, die Endlichkeit des Selbstbewußtseins und dessen Intentionalität, die ursprüngliche Mangelhaftigkeit des Für-sich angesichts des höchsten Werts, das präreflexive Cogito sowie schließlich die Aspekte, die mit dem „Primat des Praktischen“ in Verbindung stehen. Auch wenn der ‚Priester der Freiheit’ des 20. Jahrhunderts den ‚Priester der Wahrheit’ des 18. Jahrhunderts abzulösen scheint, zeigt die Autorin auf, daß Sartre in vielen Punkten als eine Art ‘französischer Fichte’ verstanden werden kann. (shrink)

Bridging the gap between the world of science and the realm of the spiritual, B. Alan Wallace introduces a natural theory of human consciousness that has its roots in contemporary physics and Buddhism. Wallace's "special theory of ontological relativity" suggests that mental phenomena are _conditioned_ by the brain, but do not _emerge_ from it. Rather, the entire natural world of mind and matter, subjects and objects, arises from a unitary dimension of reality that is more fundamental than these dualities, as (...) proposed by Wolfgang Pauli and Carl Jung. To test his hypothesis, Wallace employs the Buddhist meditative practice of _samatha_, refining one's attention and metacognition, to create a kind of telescope to examine the space of the mind. Drawing on the work of the physicist John Wheeler, he then proposes a more general theory in which the participatory nature of reality is envisioned as a self-excited circuit. In comparing these ideas to the Buddhist theory known as the Middle Way philosophy, Wallace explores further aspects of his "general theory of ontological relativity," which can be investigated by means of _vipasyana_, or insight, meditation. Wallace then focuses on the theme of symmetry in reference to quantum cosmology and the "problem of frozen time," relating these issues to the theory and practices of the Great Perfection school of Tibetan Buddhism. He concludes with a discussion of the general theme of complementarity as it relates to science and religion. The theories of relativity and quantum mechanics were major achievements in the physical sciences, and the theory of evolution has had an equally deep impact on the life sciences. However, rigorous scientific methods do not yet exist to observe mental phenomena, and naturalism has its limits for shedding light on the workings of the mind. A pioneer of modern consciousness research, Wallace offers a practical and revolutionary method for exploring the mind that combines the keenest insights of contemporary physicists and philosophers with the time-honored meditative traditions of Buddhism. (shrink)

The present paper offers a philosophical discussion of phenomena which in the empirical literature have recently been subsumed under the concept of ‘mental time travel’. More precisely, the paper considers differences and similarities between two cases of ‘mental time travel’, recollective memories (‘R-memories’) of past events on the one hand, and sensory imaginations (‘S-imaginations’) of future events on the other. It develops and defends the claim that, because a subject who R-remembers a past event is experientially aware of a past (...) particular event, while a subject who S-imagines a future event could not possibly be experientially aware of a future particular event, R-memories of past events and S-imaginations of future events are ultimately mental occurrences of two different kinds. (shrink)

Do psychological traits predict philosophical views? We administered the PhilPapers Survey, created by David Bourget and David Chalmers, which consists of 30 views on central philosophical topics (e.g., epistemology, ethics, metaphysics, philosophy of mind, and philosophy of language) to a sample of professional philosophers (N = 314). We extended the PhilPapers survey to measure a number of psychological traits, such as personality, numeracy, well-being, lifestyle, and life experiences. We also included non-technical ‘translations’ of these views for eventual use in other (...) populations. We found limited to no support for the notion that personality or demographics predict philosophical views. We did, however, find that some psychological traits were predictive of philosophical views, even after strict correction for multiple comparisons. Findings include: higher interest in numeracy predicted physicalism, naturalism, and consequentialism; lower levels of well-being and higher levels of mental illness predicted hard determinism; using substances such as psychedelics and marijuana predicted non-realist and subjectivist views of morality and aesthetics; having had a transformative or self-transcendent experience predicted theism and idealism. We discuss whether or not these empirical results have philosophical implications, while noting that 68% of our sample of professional philosophers indicated that such findings would indeed have philosophical value. (shrink)

ABSTRACT:Partnerships between companies and NGOs have received considerable attention in CSR in the past years. However, the role of NGO legitimacy in such partnerships has thus far been neglected. We argue that NGOs assume a status as special stakeholders of corporations which act on behalf of the common good. This role requires a particular focus on their moral legitimacy. We introduce a conceptual framework for analysing the moral legitimacy of NGOs along three dimensions, building on the theory of deliberative democracy. (...) Against this background we outline three procedural characteristics which are essential for judging the legitimacy of NGOs as potential or actual partners of corporations. (shrink)

ABSTRACT While multiple crisis phenomena have sparked experimentation with alternative forms of production and consumption on the micro level, it is not clear if and how these alternative practices may become hegemonic and thus displace capitalism as the hegemonic order on the macro level, rather than merely fostering pockets of a solidarity economy within capitalism. This question is hard to research, because it relates to post-capitalist futures rather than actual events or phenomena in the past or present. In this article, (...) I propose a methodological framework for studying the transformative potential of counter-hegemonic initiatives. Building on debates on causality and prediction within Critical Realism, I introduce the concept of ‘ex-ante’ retroduction. Using this mode of reasoning helps to identify possible generative mechanisms for the viability and achievability of alternative futures which can then be empirically investigated. (shrink)

Sometimes we remember past objects or events in a vivid, experiential way. The present paper addresses some fundamental questions about the metaphysics of such experiential or ‘recollective’ memories. More specifically, it develops the ‘Relational Account’ of recollective memory, which consists of the following three claims. A subject who recollectively remembers a past object or event stands in an experiential relation to the relevant past object or event. The R‐remembered object or event itself is a part of the R‐memory; that is, (...) the subject's present R‐memory is partly constituted by the relevant past object or event. When a subject R‐remembers a past object, the past object is a constitutive part of the conscious experience itself; that is, the object is immediately available to the subject in conscious experience. In developing the Relational Account, the present paper hopes to make a substantial contribution to any attempt to account for the nature of recollective memory. Furthermore, in order to explain how a subject could understand the beliefs that she forms about the past on the basis of an R‐memory, and how a subject could, on the basis of an R‐memory, gain any knowledge about the past, we arguably also need to rely on the Relational Account of recollective memory. Thus, the Relational Account will also play an important role in an attempt to account for various other ways in which a subject might be related to the past in general, and to her own past in particular. Standing in such relations to the past is, in turn, a central feature of our human existence. Ultimately, therefore, the Relational Account of recollective memory should also play a crucial role in furthering our understanding of ourselves, and of our own existence in time. (shrink)

Capitalism is often modernised and stabilised by its very critics. Gramsci called this paradox a 'passive revolution'. What are the pitfalls through which critique becomes absorbed? This question is taken up using a Cultural Political Economy approach for analysing the resistant potential of 'degrowth discourses' against the neoliberal hegemony. Degrowth advocates an economy without growth in order to achieve the transformation that is necessary in ecological and social terms. It thus does not follow the neoliberal idea of green capitalism that (...) already has absorbed much environmental critique. This paper argues that degrowth needs to be further differentiated in order to draw any conclusions about its counter-hegemonic potential. Three dimensions are identified for differentiating sub-hegemonic from counter-hegemonic degrowth positions: the mode of growth critique, the interpellation of the individual and the subsequent actions motivated. (shrink)

In their paper "Remembering," first published in the Philosophical Review in 1966, Martin and Deutscher develop what has since come to be known as the Causal Theory of Memory. The core claim of the Causal Theory of Memory runs as follows: If someone remembers something, whether it be "public," such as a car accident, or "private," such as an itch, then the following criteria must be fulfilled: 1. Within certain limits of accuracy he represents that past thing. 2. I f (...) the thing was "public," then he observed what he now represents. If the thing was "private," then it was his. 3. His past experience of the thing was operative in producing a state or successive states in him finally operative in producing his representation. These three statements express the condition which we consider to be separately necessary and jointly sufficient, if an event is to be an instance of remembering. (shrink)

_The Infrastructure of Accountability _brings together leading and emerging scholars who set forth an ambitious conceptual framework for understanding the full impact of large-scale, performance-based accountability systems on education. Over the past 20 years, schools and school systems have been utterly reshaped by the demands of test-based accountability. Interest in large-scale performance data has reached an unprecedented high point. Yet most education researchers focus primarily on questions of data quality and the effectiveness of data use. In this bold and thought-provoking (...) volume, the contributors look beneath the surface of all this activity to uncover the hidden infrastructure that supports the production, flow, and use of data in education, and explore the impact of these large-scale information systems on American schooling. These systems, the editors note, “sit at the juncture of technical networks, work practices, knowledge production, and moral order. (shrink)

The following paper considers one important feature of our experiential or ‘recollective’ memories, namely their spatial perspectival characteristics. I begin by considering the ‘Past-Dependency-Claim’, which states that every recollective memory (or ‘R-memory’) has its spatial perspectival characteristics in virtue of the subject’s present awareness of the spatial perspectival characteristics of a relevant past perceptual experience. Although the Past-Dependency-Claim might for various reasons seem particularly attractive, I show that it is false. I then proceed to develop and defend the ‘Present-Dependency-Claim’, namely (...) the claim that the spatial perspectival characteristics of an R-memory depend on the spatial perspectival characteristics of perceptual experiences that the subject has at the time at which the R-memory occurs. Lastly, I discuss the phenomenon of so-called ‘observer-memories’, which presents a special challenge for any attempt to account for the spatial perspectival characteristics of R-memories. I argue that we have no good reason to deny that the relevant experiences should count as memories, and I show that we can account for the spatial perspectival characteristics of observer-memories with the help of the ‘Present-Dependency-Claim’. More generally, the paper shows that certain events that occur in a subject’s mental life (namely, a subject’s R-memories) are necessarily dependent on other events that occur in the relevant subject’s mental life (namely, on certain perceptual experiences). This more general conclusion in turn should be relevant for any attempt to develop an appropriate account of a subject’s mental life as a whole. (shrink)

We sometimes experience emotions which are directed at past events (or situations) which we witnessed at the time when they occurred (or obtained). The present paper explores the role which such "autobiographically past-directed emotions" (or "APD-emotions") play in a subject's mental life. A defender of the "Memory-Claim" holds that an APD-emotion is a memory, namely a memory of the emotion which the subject experienced at the time when the event originally occurred (or the situation obtained) towards which the APD-emotion is (...) directed. On this view, APD-emotions might play an important role in our acquiring knowledge about our own past emotions, which renders the view rather attractive. However, as I show in the present paper, none of the various possible versions of the Memory-Claim are tenable. This leaves us with the "Universal-New-Emotion-Claim", according to which all APD-emotions are new emotional responses to the past events (or situations) towards which the relevant APD-emotions are directed. Further consideration of the "Universal-New-Emotion-Claim" shows that while APD-emotions do not play the epistemological role they could have played had some version of the Memory-Claim turned out to be true, a subject's APD-emotions nevertheless do play a vital role in a subject's mental life: they help the subject to develop a balanced sense of self. (shrink)

Memory can play two quite different roles in grief. Memories involving a deceased loved one can make them feel either enjoyably present, or especially and painfully absent. In this paper, we consider what makes it possible for memory to play these two different roles, both in grief and more generally. We answer this question by appeal to the phenomenological nature of vivid remembering, and the context in which such memories occur. We argue that different contexts can make salient different aspects (...) of memory's phenomenological nature, thus making what is remembered sometimes feel pleasantly 'present' again, and sometimes painfully absent. (shrink)

Bridging the gap between the world of science and the realm of the spiritual, B. Alan Wallace introduces a natural theory of human consciousness that has its roots in contemporary physics and Buddhism. Wallace's "special theory of ontological relativity" suggests that mental phenomena are _conditioned_ by the brain, but do not _emerge_ from it. Rather, the entire natural world of mind and matter, subjects and objects, arises from a unitary dimension of reality that is more fundamental than these dualities, as (...) proposed by Wolfgang Pauli and Carl Jung. To test his hypothesis, Wallace employs the Buddhist meditative practice of _samatha_, refining one's attention and metacognition, to create a kind of telescope to examine the space of the mind. Drawing on the work of the physicist John Wheeler, he then proposes a more general theory in which the participatory nature of reality is envisioned as a self-excited circuit. In comparing these ideas to the Buddhist theory known as the Middle Way philosophy, Wallace explores further aspects of his "general theory of ontological relativity," which can be investigated by means of _vipasyana_, or insight, meditation. Wallace then focuses on the theme of symmetry in reference to quantum cosmology and the "problem of frozen time," relating these issues to the theory and practices of the Great Perfection school of Tibetan Buddhism. He concludes with a discussion of the general theme of complementarity as it relates to science and religion. The theories of relativity and quantum mechanics were major achievements in the physical sciences, and the theory of evolution has had an equally deep impact on the life sciences. However, rigorous scientific methods do not yet exist to observe mental phenomena, and naturalism has its limits for shedding light on the workings of the mind. A pioneer of modern consciousness research, Wallace offers a practical and revolutionary method for exploring the mind that combines the keenest insights of contemporary physicists and philosophers with the time-honored meditative traditions of Buddhism. (shrink)

The present article aims to show that a subject can only fully grasp the concept of the past if she has some experiential, or recollective, memories of particular past events. More specifically, I argue that (1) in order for a subject to understand the concept of the past, it is necessary that the subject understand the concept of a particular past event in such a way that it might contribute to her understanding of the concept of the past. (2) But (...) then, in order for a subject to understand the concept of a particular past event in such a way that it might contribute to her understanding of the concept of the past, it is necessary that the subject have some recollective memories of particular past events. (C) Hence, a subject can only understand the concept of the past if she has some recollective memories of particular past events. I defend the premises of the present argument against various objections, indicate why we should accept both premises, and accordingly end by endorsing the argument's conclusion. (shrink)

It is generally acknowledged that Hobbes's radical scepticism is intimately connected with his nominalism, and that his nominalism in turn rests upon the doctrine of meaning and truth set out in its best-known version in Chapters 4 and 5 of Leviathan.

In the industrialized countries university research and state-financed research are increasingly evaluated from the point of view of their contribution to technology transfer, industrial innovation, and the competitiveness of national industries. Political debates on the viability of orienting basic research toward practical applications are paralleled by discussions, among social scientists, about the risks and opportunities of political direction over science. These debates are the frame of reference for this study, which analyzes the differences between basic and applied research, their correlates (...) and consequences, in high-temperature superconductor research in the Federal Republic of Germany. It will be shown that basic and applied research are fundamentally different in their social organization, their research goals, and their research strategies. These differences are in contrast to the call of science policy for more intense interaction and assimilation. Nevertheless, there are conditions under which basic or applied re searchers will partially follow "foreign" orientations and strategies. These conditions may, in part, be shaped by policy decisions. (shrink)

The present paper considers the question whether, and if so how, a subject's full attention to an object which she interacts with might have value. More specifically, I defend the claim that in order for a subject's activity to have value, it is sufficient that the subject give her full attention to the object towards which the activity is directed.

The present paper considers our ability to ‘shape our own mental lives’; more specifically, it considers the claim that subjects sometimes can and do engage in ‘mental self-regulation’, that is, that subjects sometimes can be, and are, actively involved with their own mental lives in a goal-directed way. This ability of mental self-regulation has been rather neglected by contemporary philosophers of mind, but I show why it deserves careful philosophical attention. In order to further our understanding of the nature of (...) the phenomenon of mental self-regulation and to locate it within the wider context of our everyday lives and the world we live in, I proceed to develop some conditions which need to be met in order for a subject to be able to engage in mental self-regulation. In developing those conditions we find that compared to the physical realm, our mental lives are a rather elusive domain in the face of attempts at intervention, and our ability to intervene in our own mental lives is rather fragile. We also find that our ability to regulate our own mental lives in many cases depends on our possession of mental skills and mental know-how. Both these observations in turn throw new light on our understanding of the nature of the human mind. (shrink)

First published in 1918, this volume was partly based on lectures delivered by Dorothea Jane Stephen at and near Bangalore and was intended to illustrate the considerable influence exercised by the early literature of India on later Indian philosophy and culture. Examining themes of divinity and religion together with morality and human nature, the essays in this book combine to offer a fitting introduction to the importance and far-reaching effects of early Indian thought.

Zusammenfassung Oft genügen geschichtswissenschaftliche Erklärungen nicht den strengen Maßstäben einer Kausalerklärung, wie sie etwa in der Physik vorkommen mag. Das heißt aber nicht, daß es in der Geschichtswissenschaft keine Erklärungen gibt. Wir haben an Beispielen gesehen, daß Historiker und Historikerinnen sehr wohl auch 'Warum?'-Fragen zu beantworten versuchen, und daß sich diese Antworten zum Teil sogar in direkte DN-bzw. IS-Erklärungen umformen lassen. Es besteht also keine Ursache, die Geschichtswissenschaft von den sogenannten "theoretischen Wissenschaften" methodologisch scharf zu trennen. Außerdem liefern nicht wenige (...) Erklärungen in geschichtswissenschaftlichen Kontexten Beispiele für normalerweise epistemisch befriedigende Erklärungsepisoden, die nicht in das Schema der strikten Kausalerklärung passen. Dazu zählen aufgrund der differenzierten Fragestellungen an Historiker auch bloße detaillierte Geschehensbeschreibungen oder teleologische Erklärungen von Handlungen. (shrink)

Zusammenfassung Oft genügen geschichtswissenschaftliche Erklärungen nicht den strengen Maßstäben einer Kausalerklärung, wie sie etwa in der Physik vorkommen mag. Das heißt aber nicht, daß es in der Geschichtswissenschaft keine Erklärungen gibt. Wir haben an Beispielen gesehen, daß Historiker und Historikerinnen (i) sehr wohl auch 'Warum?'-Fragen zu beantworten versuchen, und daß sich (ii) diese Antworten zum Teil sogar in direkte DN-bzw. IS-Erklärungen umformen lassen. Es besteht also keine Ursache, die Geschichtswissenschaft von den sogenannten "theoretischen Wissenschaften" methodologisch scharf zu trennen. Außerdem liefern (...) nicht wenige Erklärungen in geschichtswissenschaftlichen Kontexten Beispiele für normalerweise epistemisch befriedigende Erklärungsepisoden, die nicht in das Schema der strikten Kausalerklärung passen. Dazu zählen aufgrund der differenzierten Fragestellungen an Historiker auch bloße detaillierte Geschehensbeschreibungen oder teleologische Erklärungen von Handlungen. (shrink)

Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal opioid withdrawal syndrome soon after birth. Recent data demonstrates that nearly every 15 min a baby is born in the United States suffering from NOWS. The primary treatment for NOWS is opioid replacement therapy, commonly oral morphine, which has neurotoxic effects on the developing brain. There is an urgent need for non-opioid treatments for NOWS. Transcutaneous auricular neurostimulation, a novel and non-invasive form of (...) electrostimulation, may serve as a promising alternative to morphine. tAN is delivered via a multichannel earpiece electrode worn on and around the left ear, targeting two cranial nerves—the vagus and trigeminal nerves. Prior research suggests that auricular neurostimulation exerts an anxiolytic effect on the body by releasing endogenous opioids and reduces withdrawal symptoms in adults actively withdrawing from opioids. In this first-in-human prospective, open-label trial, we investigated tAN as an adjuvant to morphine therapy in eight infants >33 weeks gestational age suffering from NOWS and receiving oral morphine treatment. Infants received tAN for 30 min 1 h before receiving a morphine dose. tAN was delivered at 0.1 mA below perception intensity at two different nerve targets on the ear: Region 1, the auricular branch of the vagus nerve; and Region 2, the auriculotemporal nerve. tAN was delivered up to four times daily for a maximum of 12 days. The primary outcome measures were safety [heart rate monitoring, Neonatal Infant Pain Scale, and skin irritation] and morphine length of treatment. tAN was well-tolerated and resulted in no unanticipated adverse events. Comparing to the national average of 23 days, the average oral morphine LOT was 13.3 days and the average LOT after tAN initiation was 7 days. These preliminary data suggest that tAN is safe and may serve as a promising alternative adjuvant for treating NOWS and reducing the amount of time an infant receives oral morphine. (shrink)